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NFL Week 16 Predictions 2024: Picks & Odds for Marquee Games

C Jackson Cowart

Last Updated: December 21, 2024 9:48 PM EST • 1 min 45 sec read.

Green Bay Packers wide receiver Romeo Doubs celebrates with Green Bay Packers quarterback Jordan Love as we examine the latest NFL Week 16 odds and predictions.
Green Bay Packers wide receiver Romeo Doubs (87) celebrates with Green Bay Packers quarterback Jordan Love (10) following a touchdown pass. Photo by Joe Nicholson / Imagn Images.

Just three weeks remain in the NFL regular season as we turn our attention to the NFL Week 16 odds and predictions for the top games this week.

The action started with a Thursday Night Football odds showdown between AFC West contenders, as the Denver Broncos take on the home favorite Los Angeles Chargers for an 8:15 p.m. ET kickoff at SoFi Stadium (Prime Video).

We were treated to two more showdowns between Super Bowl odds hopefuls on Saturday, when the Kansas City Chiefs hosted the Houston Texans at 1 p.m. ET (NBC) and the Pittsburgh Steelers traveled a familiar road to face the Baltimore Ravens at 4:30 p.m. ET (FOX).

Sunday featured 12 games in total, capped off by the Dallas Cowboys playing the role of home underdogs by the Sunday Night Football odds. That one kicked off at 8:20 p.m. ET at NBC, while the Monday Night Football odds clash between the New Orleans Saints and Green Bay Packers is set for 8:15 p.m. ET (ESPN).

NFL picks & predictions Week 16

Don't miss the rest of our Week 16 NFL picks. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

NFL odds & predictions for Monday Night Football

NFL odds via our best NFL betting sites. Follow the latest NFL scores for line history and matchup info.  

Saints vs. Packers odds

Prediction: Josh Jacobs to score 2+ touchdowns (+215 via DraftKings) ⭐⭐⭐

Pick made by Mike Spector.

  • When: Monday, Dec. 23 - 8:15 p.m. ET
  • Where: Lambeau Field (Green Bay, Wis.)
  • How to watch: ABC / ESPN

NFL picks roundup: Week 16

NFL betting odds pages

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Written By:
C Jackson Cowart
C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.