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Tampa Bay Buccaneers tight end Cade Otton is tackled by Los Angeles Chargers safety Tony Jefferson as we look at the best Week 16 odds.
Tampa Bay Buccaneers tight end Cade Otton is tackled by Los Angeles Chargers safety Tony Jefferson at SoFi Stadium. Photo by Gary A. Vasquez / Imagn Images.

2024 NFL odds Week 16

(Odds via bet365)

GameSpread (Dec. 18)Moneyline (Dec. 18)Over/Under (Dec. 18)
Broncos vs. Chargers (TNF)Chargers -2.5Chargers -15042 (-110/-110)
Texans vs. Chiefs (Saturday)Chiefs -3Chiefs -15541.5 (-110/-110)
Steelers vs. Ravens (Saturday)Ravens -6.5Ravens -29044.5 (-110/-110)
Cardinals vs. PanthersPanthers +4.5Panthers +18047 (-110/-110)
Browns vs. BengalsBengals -7.5Bengals -37047 (-110/-110)
Lions vs. BearsBears +6.5Bears +24048 (-110/-110)
Rams vs. JetsJets +3Jets +15046.5 (-110/-110)
Giants vs. FalconsFalcons -8.5Falcons -45041 (-110/-110)
Eagles vs. CommandersCommanders +3Commanders +14545.5 (-110/-110)
Titans vs. ColtsColts -3.5Colts -20042.5 (-110/-110)
Vikings vs. SeahawksSeahawks +3Seahawks +14042.5 (-110/-110)
Jaguars vs. RaidersRaiders +1Raiders -11039.5 (-110/-110)
Patriots vs. BillsBills -14Bills -100046.5 (-110/-110)
49ers vs. DolphinsDolphins -1Dolphins -12044.5 (-110/-110)
Buccaneers vs. Cowboys (SNF)Cowboys +4Cowboys +17048.5 (-110/-110)
Saints vs. Packers (MNF)Packers -14Packers -100042 (-110/-110)
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The Week 16 NFL odds are out, and we are treated to a pair of Saturday games as the season winds down. Our NFL betting sites will have a busy week ahead reacting to the previous week's results and betting patterns.

  • The Thursday Night Football odds feature an AFC West showdown between the Broncos and Chargers as both teams vie for the playoffs (8:15 p.m. ET, Prime Video)
  • A Saturday doubleheader makes for a special week
    • The Texans and Chiefs, two teams that don't need to worry about their NFL playoff odds as division leaders, open the action at 1 p.m. ET (NBC/Peacock)
      • This line has moved substantially in early betting; after Chiefs QB Patrick Mahomes suffered an injury last week the Chiefs flipped to underdog status, but they've become favorites again since he returned to practice on Tuesday
    • The Steelers and Ravens square off in a key AFC North matchup at 4:30 p.m. ET (FOX)
      • Baltimore is a full touchdown favorite despite trailing Pittsburgh in the division
  • The Sunday Night Football odds have the Buccaneers lined as 4-point favorites over the Cowboys
  • The Monday Night Football odds are set for a bit of an underwhelming matchup as the Saints visit the Packers, who are favored by 14 points
  • ATS leaders heading into Week 16: Broncos (11-3), Steelers (10-4), Vikings (9-4-1)
  • ATS losers heading into Week 16: Titans (2-12), Browns (4-10), Giants (4-10)
  • Over leaders heading into Week 16: Ravens (11-3), Panthers (10-4), Bengals (10-4)
  • Under leaders heading into Week 16: Texans (4-10), Chargers (5-9), Bears (5-9), Vikings (5-9), Eagles (5-9), Giants (5-9), Falcons (5-9)

Broncos vs. Chargers odds: Thursday Night Football

  • Opening spread (Dec. 11): Chargers -3
  • Opening moneyline (Dec. 11): Chargers -160
  • Opening total (Nov. 27): 42 (-110/-110)
  • Kickoff: 8:15 p.m. ET from Sofi Stadium (Inglewood, Calif.)
  • How to watch: Prime Video

Texans vs. Chiefs odds: Saturday

  • Opening spread (Dec. 11): Chiefs -4
  • Opening moneyline (Dec. 11): Chiefs -200
  • Opening total (Nov. 27): 44.5 (-110/-110)
  • Kickoff: 1 p.m. ET from GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
  • How to watch: NBC/Peacock

Steelers vs. Ravens odds: Saturday

  • Opening spread (Dec. 11): Ravens -4.5
  • Opening moneyline (Dec. 11): Ravens -210
  • Opening total (Nov. 27): 46.5 (-110/-110)
  • Kickoff: 4:30 p.m. ET from M&T Bank Stadium (Baltimore)
  • How to watch: FOX

Buccaneers vs. Cowboys odds: Sunday Night Football 

  • Opening spread (Dec. 11): Cowboys +3.5
  • Opening moneyline (Dec. 11): Cowboys +165
  • Opening total (Nov. 27): 47 (-110/-110)
  • Kickoff: 8:20 p.m. ET from AT&T Stadium (Arlington, Texas)
  • How to watch: NBC/Peacock

Saints vs. Packers odds: Monday Night Football

  • Opening spread (Dec. 11): Packers -13
  • Opening moneyline (Dec. 11): Packers -850
  • Opening total (Nov. 27): 42 (-110/-110)
  • Kickoff: 8:15 p.m. ET from Lambeau Field (Green Bay, Wis.)
  • How to watch: ESPN/ABC

NFL Week 16 odds and lines

There's an advantage to betting the early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

NFL betting odds pages

Here are our best NFL betting sites:

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