NFL Week 12 Predictions 2024: Picks & Odds for Marquee Games

C Jackson Cowart

Last Updated: November 19, 2024 8:30 AM EST • 3 min 54 sec read. Twitter link Google News Link

Baltimore Ravens quarterback Lamar Jackson (8) is brought down as we offer our NFL Week 12 predictions and odds for this week. — Baltimore Ravens quarterback Lamar Jackson (8) is brought down by Los Angeles Chargers linebacker Tuli Tuipulotu (45). Photo by Gary A. Vasquez / Imagn Images.

After a busy (and consequential) week around the league, we're looking ahead to a slightly smaller slate this week as we offer our NFL Week 12 odds and predictions.

The week starts with a Thursday Night Football odds showdown between division rivals when the Pittsburgh Steelers travel to face the Cleveland Browns at 8:15 p.m. ET on Prime Video. Another win could do wonders for the Steelers' Super Bowl odds.

Sunday's slate features 11 games, most of which profile as potential blowouts, though the Sunday Night Football odds expect a close contest between the Philadelphia Eagles and host Los Angeles Rams at 8:20 p.m. ET on NBC.

The NFL Week 12 odds conclude with a family affair between the Baltimore Ravens and Los Angeles Chargers, which will mark the third-ever matchup between brothers John Harbaugh and Jim Harbaugh. The Ravens are favorites by the Monday Night Football odds with kickoff set for 8:15 p.m. ET on ESPN.

NFL picks & predictions Week 12

Steelers vs. Browns early picks (TNF)

Steelers vs. Browns prediction
Steelers vs. Browns player props
Steelers vs. Browns parlay
Russell Wilson player prop bets
Nick Chubb player prop bets
TNF anytime touchdown scorer predictions
TNF first touchdown scorer predictions

Vikings vs. Bears player props
Lions vs. Colts prediction

Lions vs. Colts player props
Lions vs. Colts anytime touchdown scorer predictions

Patriots vs. Dolphins player props
49ers vs. Packers prediction

49ers vs. Packers player props

Cardinals vs. Seahawks player props
Eagles vs. Rams early picks (SNF)

Eagles vs. Rams prediction
Eagles vs. Rams player props
Eagles vs. Rams parlay
Jalen Hurts player prop bets
Puka Nacua player prop bets
SNF first touchdown scorer predictions

Ravens vs. Chargers early picks (MNF)

Ravens vs. Chargers prediction
Ravens vs. Chargers player props

Don't miss the rest of our Week 12 NFL picks. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

NFL odds & predictions for Thursday Night Football

NFL odds via BetMGM and subject to change. Follow the latest NFL scores for line history and matchup info.

Steelers vs. Browns odds

Pittsburgh Steelers quarterback Russell Wilson throws a pass as we offer our NFL Week 12 odds and predictions. — Pittsburgh Steelers quarterback Russell Wilson throws a pass against the Baltimore Ravens. Photo by Barry Reeger via Imagn Images.

When: Thursday, Nov. 21 - 8:15 p.m. ET
Where: Huntington Bank Field (Cleveland)
How to watch: Prime Video
Moneyline: Steelers -210 | Browns +170
Spread: Steelers -3.5 (-120) | Browns +3.5 (-110)
Total: 36.5 (-110/-110)

NFL odds & predictions for Sunday

Titans vs. Texans odds

Houston Texans wide receiver Nico Collins (12) signals after a first down as we offer our NFL Week 12 odds and predictions. — Houston Texans wide receiver Nico Collins (12) signals after a first down. Photo by Troy Taormina / Imagn Images.

When: Sunday, Nov. 24 - 1 p.m. ET
Where: NRG Stadium (Houston)
How to watch: CBS
Moneyline: Titans +320 | Texans -400
Spread: Titans +8 (-110) | Texans -8 (-110)
Total: 41.5 (-110/-110)

Cowboys vs. Commanders odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: Northwest Stadium (Landover, Md.)
How to watch: FOX
Moneyline: Cowboys +450 | Commanders -650
Spread: Cowboys +10.5 (-110) | Commanders -10.5 (-110)
Total: 45.5 (-110/-110)

Chiefs vs. Panthers odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: Bank of America Stadium (Charlotte, N.C.)
How to watch: CBS
Moneyline: Chiefs -650 | Panthers +450
Spread: Chiefs -11 (-110) | Panthers +11 (-110)
Total: 41.5 (-110/-110)

Lions vs. Colts odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: Lucas Oil Stadium (Indianapolis)
How to watch: FOX
Moneyline: Lions -375 | Colts +290
Spread: Lions -8 (-110) | Colts +8 (-110)
Total: 50.5 (-110/-110)

Buccaneers vs. Giants odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: MetLife Stadium (East Rutherford, N.J.)
How to watch: CBS
Moneyline: Buccaneers -250 | Giants +190
Spread: Buccaneers -5 (-110) | Giants +5 (-110)
Total: 42 (-110/-110)

Patriots vs. Dolphins odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: Hard Rock Stadium (Miami Gardens, Fla.)
How to watch: CBS
Moneyline: Patriots +280 | Dolphins -350
Spread: Patriots +7 (-110) | Dolphins -7 (-110)
Total: 46 (-110/-110)

Vikings vs. Bears odds

When: Sunday, Nov. 24 - 1 p.m. ET
Where: Soldier Field (Chicago)
How to watch: FOX
Moneyline: Vikings -190 | Bears +155
Spread: Vikings -3.5 (-110) | Bears +3.5 (-110)
Total: 39.5 (-110/-110)

Broncos vs. Raiders odds

Denver Broncos quarterback Bo Nix prepares to take a snap as we offer our NFL Week 12 odds and predictions. — Denver Broncos quarterback Bo Nix prepares to take a snap. Photo by Ron Chenoy / Imagn Images.

When: Sunday, Nov. 24 - 4:05 p.m. ET
Where: Allegiant Stadium (Las Vegas)
How to watch: CBS
Moneyline: Broncos -250 | Raiders +195
Spread: Broncos -5.5 (-110) | Raiders +5.5 (-110)
Total: 41 (-110/-110)

49ers vs. Packers odds

When: Sunday, Nov. 24 - 4:25 p.m. ET
Where: Lambeau Field (Green Bay, Wis.)
How to watch: FOX
Moneyline: 49ers +115 | Packers -140
Spread: 49ers +2.5 (-110) | Packers -2.5 (-110)
Total: 47.5 (-110/-110)

Cardinals vs. Seahawks odds

When: Sunday, Nov. 24 - 4:25 p.m. ET
Where: Lumen Field (Seattle)
How to watch: FOX
Moneyline: Cardinals -110 | Seahawks -110
Spread: Cardinals -1 (-105) | Seahawks +1 (-115)
Total: 47.5 (-110/-110)

NFL odds & predictions for Sunday Night Football

Eagles vs. Rams odds

Los Angeles Rams quarterback Matthew Stafford waits for a timeout as we offer our NFL Week 12 odds and predictions. — Los Angeles Rams quarterback Matthew Stafford waits for a timeout. Photo by Joe Nicholson / Imagn Images.

When: Sunday, Nov. 24 - 8:20 p.m. ET
Where: SoFi Stadium (Inglewood, Calif.)
How to watch: NBC
Moneyline: Eagles -160 | Rams +135
Spread: Eagles -3 (-110) | Rams +3 (-110)
Total: 50 (-115/-105)

NFL odds & predictions for Monday Night Football

Ravens vs. Chargers odds

Los Angeles Chargers quarterback Justin Herbert following victory as we offer our NFL Week 12 odds and predictions. — Los Angeles Chargers quarterback Justin Herbert following the victory against the Cincinnati Bengals. Photo by Gary A. Vasquez / Imagn Images.

When: Monday, Nov. 25 - 8:15 p.m. ET
Where: SoFi Stadium (Inglewood, Calif.)
How to watch: ESPN
Moneyline: Ravens -160 | Chargers +135
Spread: Ravens -3 (-110) | Chargers +3 (-110)
Total: 50 (-110/-110)

NFL picks roundup: Week 12

NFL Week 12 ATS picks
NFL Week 12 upset picks
NFL Week 12 best bets
NFL Week 12 player props
NFL Week 12 anytime touchdown scorer predictions
NFL Week 12 touchdown parlay

NFL betting odds pages

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NFL Playoff Odds	NFL Draft Odds

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Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.