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Green Bay Packers quarterback Jordan Love (10) calls plays at the line of scrimmage as we look at the Monday Night Football odds for Week 16.
Green Bay Packers quarterback Jordan Love (10) calls plays at the line of scrimmage. Photo by Steven Bisig-Imagn Images.

Well, they play the games for a reason.

That's what fans and bettors should be telling themselves as the Monday Night Football odds and betting lines for Week 16 list the host Green Bay Packers as 13.5-point favorites at Lambeau Field against the New Orleans Saints. The game will kick off at 8:15 p.m. ET on ESPN and ABC.

The already lopsided NFL Week 16 odds shifted further in Green Bay's direction as injuries piled up even more for New Orleans in its loss to the Washington Commanders last week. Meanwhile, the Packers trounced the Seattle Seahawks to improve their Super Bowl odds with just three games to go in the regular season.

Who's playing Monday Night Football this week?

Saints vs. Packers (-13.5), 8:15 p.m. ET

Here are the betting trends for both teams entering Week 16:

SaintsPackers
Moneyline5-910-4
Spread6-88-6
Over/Under7-76-7-1

Monday Night Football odds Week 16: Saints vs. Packers

Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Monday Night Football picks

Monday Night Football 2024 results

WeekResultATSTotal
Week 149ers 32, Jets 1949ers -3.5O43.5
Week 2Falcons 22, Eagles 21Falcons +5.5U46.5
Week 3Bills 47, Jaguars 10Bills -4.5O46.5
Week 3Commanders 38, Bengals 33Commanders +7.5O46.5
Week 4Titans 31, Dolphins 12Titans +2.5O37.5
Week 4Lions 42. Seahawks 29Lions -4.5O47.5
Week 5Chiefs 26, Saints 13Chiefs -5.5U43.5
Week 6Bills 23, Jets 20Bills -1.5O42.5
Week 7Ravens 41, Buccaneers 31Ravens -4.5O51.5
Week 7Cardinals 17, Chargers 15Cardinals +1.5U44.5
Week 8Steelers 26, Giants 18Steelers -6.5O37.5
Week 9Chiefs 30, Buccaneers 24Buccaneers +8.5O45.5
Week 10 Dolphins 23, Rams 15Dolphins +2U49.5
Week 11Texans 34, Cowboys 10Texans -7.5O41.5
Week 12Ravens 30, Chargers 23Ravens -2.5O50.5
Week 13Broncos 41, Browns 32Broncos -6.5O41.5
Week 14Bengals 27, Cowboys 20Bengals -4.5U50.5
Week 15Vikings 30, Bears 12Vikings -6.5U43.5
Week 15Falcons 15, Raiders 9Falcons -5.5U43.5

Don't miss our lists of the best NFL parlay betting sites and top NFL prop betting sites!

Monday Night Football 2024-25 schedule & how to watch

Week MatchupTime (ET)TV
Week 16Saints vs. Packers8:15 p.m. ETESPN 
Week 17Lions vs. 49ers8:15 p.m. ETESPN/ABC

Check out our Super Bowl odds and picks here!

Monday Night Football betting tips

Get an early start

The Monday Night Football game is a big deal for betting each week. This brings lots of bets and changes in the odds, especially from those chasing their losses after a tough Sunday betting slate. Watch the lines and totals when they start. If they go the way you like, you can wait. If they move against you, think about acting sooner.

Embrace in-game betting

While you might struggle to find value in the most popular markets for any marquee prime-time NFL game, you're sure to unearth some worthwhile plays once the game starts. Live betting might not be your thing when there are a handful of games going on at the same time, but Monday Night Football is the perfect time to lay into some live action via our best live betting sites.

Be wary of winter weather

Things can get pretty frightful outside later in the NFL season – particularly when the sun goes down. Our guide on how to bet on the NFL offers tips for how to approach betting on cold-weather games.

Check out our list of the best sportsbook promos here!

Monday Night Football FAQs

Who will make the most Monday Night Football appearances in 2024?

The most appearances by any team on Monday Night Football this season will be two. The New York Jets, San Francisco 49ers, Atlanta Falcons, Buffalo Bills, Cincinnati Bengals, Baltimore Ravens, Tampa Bay Buccaneers, Los Angeles Chargers, Kansas City Chiefs, Miami Dolphins, Dallas Cowboys, New Orleans Saints, and Detroit Lions share the honor.

Which team has the most MNF wins all-time?

The Pittsburgh Steelers have the most Monday Night wins in NFL history with 56. San Francisco (52) and Dallas (51) are the only other franchises with 50 or more MNF wins all-time.

What is the most common MNF matchup?

The Denver Broncos and Las Vegas Raiders have met a whopping 20 times on Monday Night Football, more than any other teams in league history. The Broncos own a 10-9-1 edge all-time.

NFL betting odds pages

Check out our best NFL betting sites:

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