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Miami Dolphins cornerback Kendall Fuller tackles Buffalo Bills running back James Cook as we make our best Chiefs vs. Bills NFL player prop bets & touchdown picks.
Miami Dolphins cornerback Kendall Fuller tackles Buffalo Bills running back James Cook. Photo by: Gregory Fisher-Imagn Images

The Buffalo Bills host the Kansas City Chiefs in a game that could very well come down to the rushing attacks. If you trust the Super Bowl odds, it could also be a preview of the AFC Championship game.

Though quarterbacks Patrick Mahomes and Josh Allen headline this game, my best Chiefs vs. Bills player prop bet picks focus on the rushing attacks rather than the passing attacks.

Kareem Hunt will face the 15th-ranked run defense in football, while James Cook will battle the third-ranked unit. As we make our Week 11 NFL predictions, we ask: Will either back have success?

Despite the Chiefs being undefeated, the Bills are favored by two points in Sunday’s 4:25 p.m. ET (CBS) game at Highmark Stadium in Orchard Week, N.Y. If Amari Cooper returns to the field, can the Bills’ offense do enough to win?

Chiefs vs. Bills NFL player prop bets: Sunday

Odds as of Friday and subject to change.

NFL picks made Friday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Chiefs vs. Bills touchdown pick

Amari Cooper anytime touchdown scorer (+190) ⭐⭐⭐

I’m going with Cooper for my touchdown play. While he has missed the last two games with a wrist injury, he remains optimistic that he will play. He logged limited practices this week, but there's no guarantee he'll suit up. If he does, I like him as a three-star play.

Allen has thrown 17 touchdown passes this season, but no receiver has caught more than three. This week, Allen gets a solid matchup against a pass defense that allows 1.4 passing touchdowns per game. Which receiver is he likely to target most often?

He’s only played one full game with the Bills, and he ended that contest with four catches for 66 yards and a touchdown.

Some of our best sports betting apps are pricing this at +165 or worse. At +190, Caesars is seeing something no other sportsbook is, so take advantage of their potential miscalculation.

Best odds: +190 via Caesars | Implied probability: 34.48%

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Best Chiefs vs. Bills prop bets

Kareem Hunt Over 61.5 rushing yards (-114) ⭐⭐⭐⭐

Don’t be fooled by the Bills having the 15th-ranked run defense in the league. While they’re only giving up 123.2 rushing yards per game, they’re allowing 4.9 yards per attempt, the fourth-worst mark in the league. Last week, the Denver Broncos ran for 121 yards against them and averaged 5.5 yards per carry.

Hunt has been very productive since joining the Chiefs. He has at least 14 carries in every game, and he’s managed at least 62 yards in four of his six contests. He’s only averaging 3.6 yards per carry, but he should see that number go up against the Bills’ defense on Sunday.

Some of the sites with the best sportsbook promos have this total set at 65.5 yards. While bet365 offers -110 for the Over, others are asking -118 or worse. Though the price at FanDuel isn’t as good as the one at bet365, it’s more than fair considering the four-yard difference.

Best odds: -114 via FanDuel | Implied probability: 53.27%

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James Cook Under 57.5 rushing yards (-110) ⭐⭐⭐⭐

It’s been an up-and-down season for Cook thus far. While touchdowns have come easy, he’s struggled to gain yards consistently. This year, he has five games with more than 50 yards and four games with fewer. 

The Chiefs have the third-best run defense in football, and unlike the Bills, their total rushing yards allowed statistics aren’t skewed by teams simply not running the ball against them. The Chiefs rank second in the league in yards allowed per attempt, holding opponents to just 3.7 yards per carry. 

At our best sportsbooks, the total is listed at either 56.5 or 57.5. Right now, Bet365 is offering the best price for the Under, and the sportsbook has the total set at the higher of the two numbers.

Best odds: -110 via bet365 | Implied probability: 52.38%

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Chiefs vs. Bills game info

  • When: Sunday, Nov. 17
  • Kickoff: 4:25 p.m. ET
  • Where: Highmark Stadium (Orchard Park, N.Y.)
  • How to watch: CBS
  • Weather: 52 degrees, 20% chance of precipitation, wind 9 mph SW
  • Favorite: Bills -2 (-110 via DraftKings)

NFL betting odds pages

Here are our best NFL betting sites:

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