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Oregon Ducks quarterback Dillon Gabriel drops back for a pass during the second half against the Michigan State Spartans at Autzen Stadium as we look at our Oregon vs. Wisconsin prediction.
Oregon Ducks quarterback Dillon Gabriel drops back for a pass during the second half against the Michigan State Spartans at Autzen Stadium. Photo by Troy Wayrynen/Imagn Images.

Our Oregon vs. Wisconsin prediction doesn’t expect much of a letdown for the Ducks this weekend.

No. 1 Oregon is 10-0 entering Saturday’s road trip to face Wisconsin at Camp Randall Stadium at 7:30 p.m. ET (NBC). The Ducks are two-touchdown favorites, but the Badgers are motivated while coming off a bye following losses to Iowa and Penn State.

Here's the best way to bet on Saturday’s Big Ten battle featuring a team in the Ducks that ranks second in the college football championship odds.

Best Oregon vs. Wisconsin picks

College football picks based on the odds from our best college football betting sites. Odds subject to change.

  • Against the spread pick: Oregon -13.5 (-110 via FanDuel) vs. Wisconsin ⭐⭐⭐
  • My best bet: Dillon Gabriel Over 263.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐

Oregon vs. Wisconsin against the spread prediction: Week 12

Oregon to cover the spread: - 13.5 (-110) ⭐⭐⭐

Oregon vs. Wisconsin opening odds:

  • Oregon: -14.5 (-110 via FanDuel)
  • Wisconsin: +14.5 (-110 via FanDuel)

This is where it gets interesting if you tailed my 12/1 bet on Oregon to win it all as part of my favorite 2025 college football championship picks in January. The Ducks can’t afford any missteps down the stretch, and the Badgers are hungry for an upset.

But I don’t expect that to be the case, and the market pushing this spread from 14.5 through a key number has created a buying opportunity for the Ducks. After all, they've answered every test thus far.

Road dominance

My favorite aspect of Dan Lanning’s Ducks is how locked in they are on the goal. Since Lanning turned down the opportunity to be the Alabama head coach, Oregon has been focused on being one of the best teams in the sport.

The team’s success on the road has made that clear.

The Ducks are somehow better in hostile environments this year, posting an average margin of victory of 28 points in their four road games. Oregon has recorded three-plus touchdown wins in all four road tilts. And Oregon has registered 20-plus-point victories in seven of its last eight games.

The Ducks will continue to dominate on Saturday, which is why most of our best sportsbooks charge -115 for this ticket. FanDuel is the lone shop offering -110 odds to lay -13.5.

Best odds: -110 via FanDuel | Implied probability: 52.38%

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Oregon vs. Wisconsin best bet

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Dillon Gabriel Over 263.5 passing yards (-114) ⭐⭐⭐⭐

Fanatics has set Dillon Gabriel’s passing yardage prop as low as 260.5, so I’d suggest shopping there if you can access that book. But this line at FanDuel is also a four-star play based on my projection of 295 passing yards for the Oregon quarterback.

Gabriel, who sits second in the Heisman Trophy odds, has been averaging 285 passing yards per game this season, clearing this mark in seven contests. Wisconsin has fared well against the pass this year, but Gabriel and Co. are a completely different test. 

I expect Gabriel to get the best of the Badgers’ secondary and cash one of your college football Week 12 predictions.

Best odds: -114 via FanDuel | Implied probability: 53.27%

Oregon vs. Wisconsin odds

See all of this week's college football odds and NCAAF scores.

Oregon vs. Wisconsin game info

  • When: Saturday, Nov. 16
  • Kickoff: 7:30 p.m. ET
  • Where: Camp Randall Stadium
  • How to watch: NBC
  • Weather: 48 degrees, 30% chance of precipitation, 16-mph winds S
  • Favorite: Oregon -13.5 (-115 via BetMGM)

College football betting odds pages

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