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Tennessee quarterback Nico Iamaleava against Mississippi State. Tennessee vs. Georgia is the biggest game of our Week 12 college football predictions.
Tennessee quarterback Nico Iamaleava against Mississippi State. Photo by Caitie McMekin/News Sentinel/USA TODAY NETWORK via Imagn Images.

With just a few weeks left in the season, our Week 12 college football predictions highlight the most important games.

  • Led by Heisman Trophy odds favorite Travis Hunter, Colorado takes on Utah as the Buffaloes inch closer to qualifying for the Big 12 Championship
  • Georgia's loss to Ole Miss pushed the Bulldogs down the college football championship odds, but a win against Tennessee can help Kirby Smart's program bounce back
  • BYU barely survived Utah and now has a tough Big 12 After Dark matchup with Kansas as the Cougars try to remain the conference's best College Football Playoff odds bet

The Week 12 schedule isn't full of AP Top 25 matchups, but if this season has taught us anything, it's that the biggest upsets come when we're least expecting them.

College football picks & predictions Week 12

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Don't miss the rest of our Week 12 college football picks.

College football odds for Saturday

Oregon vs. Wisconsin odds

Prediction: Dillon Gabriel Over 263.5 passing yards (-114 via FanDuel) ⭐⭐⭐⭐

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Pick made by Shane Jackson

  • When: Saturday, Nov. 16 (7:30 p.m. ET)
  • Where: Camp Randall Stadium (Madison, WIS)
  • How to watch: NBC
  • Moneyline: Oregon (-500) | Wisconsin (+380)
  • Spread: Oregon -13.5 (-112) | Wisconsin +13.5 (-108)
  • Total: 51 (-110/-110)

Tennessee vs. Georgia odds

Prediction: Dylan Sampson Under 92.5 rushing yards (-114 via FanDuel) ⭐⭐⭐

Pick made by Phil Wood

  • When: Saturday, Nov. 16 (7:30 p.m. ET)
  • Where: Sanford Stadium (Athens, Ga.)
  • How to watch: ABC
  • Moneyline: Tennessee (+295) | Georgia (-375)
  • Spread: Tennessee +8.5 (-110) | Georgia -8.5 (-110)
  • Total: 48.5 (-110/-110)

Kansas vs. BYU odds

Prediction: Jalon Daniels Over 35.5 rushing yards (-114 via FanDuel) ⭐⭐⭐⭐

Pick made by Mike Spector

  • When: Saturday, Nov. 16 (10:15 p.m. ET)
  • Where: LaVell Edwards Stadium (Provo, Utah)
  • How to watch: ESPN
  • Moneyline: Kansas (+136) | BYU (-162)
  • Spread: Kansas +3 (-102) | BYU -3 (-118)
  • Total: 55.5 (-110/-110)

College football picks roundup: Week 12

College football betting odds pages

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