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Indiana vs. Notre Dame Early Picks, Predictions & Odds: College Football Playoff

Gabe Henderson

Last Updated: December 16, 2024 10:01 AM EST • 3 min 3 sec read.

Notre Dame Fighting Irish quarterback Riley Leonard runs the ball as we make our Indiana vs. Notre Dame predictions for the College Football Playoff clash.
Notre Dame Fighting Irish quarterback Riley Leonard (13) runs the ball. Photo by Gary A. Vasquez-Imagn Images.

The inaugural 12-team College Football Playoff is just days away, with Indiana and Notre Dame kicking off the festivities on Friday evening.

Our Indiana vs. Notre Dame early picks and odds take a look at the current markets and find leans for interested bettors. We make our favorite prediction for the game as a part of our college football bowl game picks against the spread.

This intrastate showdown is one of the more intriguing first-round matchups. The Fighting Irish (-7.5) remain early favorites during the buildup to this contest at our best sports betting sites. But will this line hold once the betting public gets more invested?

Our college football bowl game opt-out tracker has you covered with the latest opt-out news and the impact on the college bowl game odds. 

My early Indiana vs. Notre Dame prediction: College Football Playoff

College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: Notre Dame -7.5

Best odds: -105 via BetMGM | Implied probability: 51.22%

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Notre Dame is one of the country's hottest teams, and it has been since slipping up against Northern Illinois. The Fighting Irish own the best average margin of victory this season (plus-26.3), and they've been steamrolling their way into the College Football Playoff.

We like the hosts to cover the spread mainly due to matchups. Indiana has been struggling against teams with strength in the trenches (Michigan and Ohio State, for example). Notre Dame's offensive line was a semifinalist for the Joe Moore Award, just like the Buckeyes' unit, and that could spell trouble for the Hoosiers.

Public action has been influencing the odds, with 55% of spread bets at BetMGM on the visitors. But are the best sportsbooks brave enough to eliminate the hosts' hook before kickoff?

That's worth monitoring throughout the week. But right now our best college football betting sites are featuring Notre Dame at -105 to cover the 7.5-point spread.

Don't miss our guide for how to bet on college football or this week's best sportsbook promos.

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Indiana vs. Notre Dame live odds

See the college football odds from our best college football betting sites for every college football bowl game.

Moneyline

We may not see the best sports betting sites knock off the hook on the spread if the public keeps backing Indiana as kickoff inches closer. But those returns could show up in the moneyline odds instead.

As such, it would be profitable for Notre Dame backers to wait for a better price, though the difference is marginal with heavily juiced favorites.

Spread

The best sports betting apps all agree while setting this line at Notre Dame -7.5. I therefore don't envision it being bet down to a touchdown.

Those looking to wager on the Fighting Irish can find the best price at BetMGM. Meanwhile, Indiana +7.5 is available for the standard juice at FanDuel.

Over/Under

  • Over best odds: 51 (-110) via Caesars
  • Under best odds: 51.5 (-115) via FanDuel

These in-state foes enter this contest with a 16-8 record toward the Over. Caesars offers the best price on the Over at 51 points (-110), whereas FanDuel is posting a total of 51.5 at -115.

Early action shows 66% of all O/U bets are on the Over. So lock in the price now at the normal vig if that's your play.

How to watch the College Football Playoff

  • When: Friday, Dec. 20
  • Kickoff: 8 p.m. ET
  • Where: Notre Dame Stadium (South Bend, Ind.)
  • How to watch: ABC/ESPN+
  • Weather: 23 degrees, 30% chance of precipitation, wind 8 mph NNE
  • Favorite: Notre Dame -7.5 (-105 via BetMGM)

College football betting odds pages

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Written By:
Gabe Henderson
Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC. Sports betting has not yet been legalized in Gabe's home state of Texas, so he frequently takes trips to Louisiana when he has the itch to place futures. Outside of work, Gabe considers himself an old head as he used an AOL email account until 2022 and still collects vinyl records.