Clemson vs. Pittsburgh Prediction, Picks & Odds: Week 12
The ACC sends No. 17 Clemson on the road to face 7-2 Pittsburgh for a noon ET (ESPN) game at Acrisure Stadium in Pittsburgh on Saturday.
The Tigers are coming off a 24-14 win on the road against Virginia Tech, while the Panthers have lost two consecutive games, which has killed their College Football Playoff odds.
Our Clemson vs. Pittsburgh prediction thinks the Tigers will thrive on the road against the Panthers thanks to the improved play of QB Cade Klubnik.
In the best ACC game of our Week 12 college football predictions, don't expect a shootout.
Best Clemson vs. Pittsburgh picks
College football picks based on the odds from our best college football betting sites. Odds subject to change.
- Against the spread pick: Clemson -11.5 (-110 via Caesars) vs. Pittsburgh ⭐⭐⭐⭐
- My best bet: Under 53 (-110 via Caesars) ⭐⭐⭐⭐⭐
Clemson vs. Pittsburgh against the spread prediction: Week 12
Clemson to cover the spread: -11.5 (-110) ⭐⭐⭐⭐
Clemson vs. Pittsburgh opening odds:
- Clemson: -9.5 (-110)
- Pittsburgh: +9.5 (-110)
Clemson’s offense has been on a tear in 2024 since being held under 200 total yards in a 34-3 Week 1 loss to Georgia. Klubnik has been the difference-maker, throwing three or more touchdowns in six of the Tigers’ nine games, including three of the last four matchups.
Running back Phil Mafah remains the workhorse out of Clemson’s backfield, which collectively averages 5.4 yards per carry and has 17 rushing touchdowns this season.
Pitt’s defense has allowed 300 or more yards of offense in eight consecutive games, and excluding a five-interception outing against Syracuse, the Panthers have struggled to consistently generate turnovers.
Clemson’s offense will be able to have its way against Pitt’s defense, which is why backing the Tigers to cover -11.5 is worth a one-unit investment.
Pitt struggles
Pitt has struggled on offense in three of its previous four games played. The Panthers have been held under 20 points twice during this stretch, including a 17-15 home win over Cal, while falling 24-19 to Virginia at home in Week 11.
Clemson’s defense is no pushover, holding four of its past five opponents under 3.1 YPC. The Tigers’ pass defense has also limited five of the past six teams it has faced to a 56% completion rate or worse.
There’s very few scenarios where Pitt covers +11.5, barring a barrage of turnovers from Klubnik. The Panthers have struggled on both sides of the football lately during conference play, which is why Clemson’s built to win this road game by 12 or more points on Saturday.
Best odds: -110 via Caesars | Implied probability: 52.38%
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Clemson vs. Pittsburgh best bet
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Under 53 (-110) ⭐⭐⭐⭐
Clemson is allowing just 23.1 points per game this season and has only given up more than 30 four times. Yes, the Tigers struggled to contain Louisville’s rushing attack in Week 10, allowing 7.8 YPC and three rushing touchdowns, but Pitt does not have the same type of explosive backfield.
The Panthers have been held to 4.0 YPC or less in four of their last five games, scoring two total rushing touchdowns in their past three outings combined. The passing attack will be leaned on when they inevitably fall behind and it's led to five interceptions since their win over Cal in mid-October.
Clemson’s defense has held opponents to 14 or fewer points in four of seven ACC contests, so let’s back the Tigers to continue this trend in a game that will likely end 35-13 or 38-10 in favor of Clemson.
Best odds: -110 via Caesars | Implied probability: 52.38%
Clemson vs. Pittsburgh odds
See all of this week's college football odds and NCAAF scores.
Clemson vs. Pittsburgh game info
- When: Saturday, Nov. 16
- Kickoff: Noon ET
- Where: Acrisure Stadium (Pittsburgh, Pa.)
- How to watch: ESPN
- Weather: 50 degrees, 0% chance of precipitation, wind 7 mph NW
- Favorite: Clemson -11.5 (-110 via Caesars)
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